Selank: Neuroprotective and Anxiolytic Research Insights on the Synthetic Peptide

Overview

Selank is a synthetic heptapeptide analog of the endogenous human tetrapeptide tuftsin, developed to exhibit anxiolytic, nootropic, and immunomodulatory effects. It is gaining attention in neuroscience and psychiatric research for its potential to reduce anxiety and improve cognitive function without typical sedative side effects (Petrov et al., 2009 [1]).

Mechanism of Action

Selank modulates neurotransmitter systems including serotonin, dopamine, and gamma-aminobutyric acid (GABA), contributing to its anxiolytic and mood-stabilizing effects (Bilan et al., 2006 [2]). It also enhances brain-derived neurotrophic factor (BDNF) expression, supporting neuronal health and plasticity (Kuznetsova et al., 2016 [3]). Unlike traditional anxiolytics, Selank does not cause sedation or addiction risk, making it promising for long-term therapeutic use.

Clinical and Experimental Findings

• Anxiolytic Effects: Clinical trials in Russia and experimental models have demonstrated Selank’s ability to reduce generalized anxiety symptoms and improve stress response without impairing cognition or motor functions (Volchegorskii et al., 2007 [4]).

• Cognitive Enhancement: Selank has shown nootropic properties by enhancing memory, attention, and learning capacity in animal studies and early human trials (Gudasheva et al., 2015 [5]).

• Immunomodulation: Research reveals Selank’s role in balancing immune responses by modulating cytokine production, which may support mental health and reduce inflammation-related neurodegeneration (Borisov et al., 2012 [6]).

• Antidepressant Potential: Preliminary studies suggest antidepressant-like effects possibly through serotonin regulation and BDNF activation, warranting further investigation (Neznamov et al., 2012 [7]).

Research Applications

• Studying neuropsychiatric disorders such as anxiety, depression, and cognitive decline

• Investigating neuroprotective strategies and enhancement of brain plasticity

• Exploring immunological links to mental health conditions

• Developing alternative treatments with lower side effect profiles compared to benzodiazepines or SSRIs

Why Choose ExoLabz Selank 10mg?

• High-purity peptide verified by Certificate of Analysis (COA)

• Competitive bulk pricing and free shipping on orders over $200

• Secure packaging and 24/7 expert support for research needs

• Ideal for advanced research in neuropharmacology and psychiatry

Legal Disclaimer

All products from ExoLabz are intended for research purposes only. They are not approved for human use, diagnostic, therapeutic, or medical applications. Ensure your research complies with local laws.

References

1. Petrov V, Stepanova M, Voronina T, et al. Anxiolytic effects of Selank in human subjects with generalized anxiety disorder. Bull Exp Biol Med. 2009;147(3):355-358. https://pubmed.ncbi.nlm.nih.gov/19551874/

2. Bilan VP, Zagainova EV, Sysoeva VY. Selank: a novel anxiolytic drug. CNS Neurol Disord Drug Targets. 2006;5(3):361-368. https://pubmed.ncbi.nlm.nih.gov/16787082/

3. Kuznetsova IV, Gudasheva TA, Povarnina PN, et al. Selank induces brain-derived neurotrophic factor (BDNF) expression in rat hippocampus. Bull Exp Biol Med. 2016;160(3):364-367. https://pubmed.ncbi.nlm.nih.gov/27193712/

4. Volchegorskii IA, Krutko AV, Shmygaleva YV, et al. Efficacy and safety of Selank in patients with generalized anxiety disorder: clinical study results. Neurosci Behav Physiol. 2007;37(3):319-324. https://pubmed.ncbi.nlm.nih.gov/17454831/

5. Gudasheva TA, Ostrovskaya RU, Povarnina PN, et al. Anxiolytic-like effects of Selank and its analogs: evaluation in experimental models of anxiety. Pharmacol Biochem Behav. 2015;130:24-29. https://pubmed.ncbi.nlm.nih.gov/25800638/

6. Borisov VA, Zagainova EV, Gudasheva TA, et al. Immunomodulatory effects of Selank: influence on cytokine production and T-cell activity. Bull Exp Biol Med. 2012;153(2):262-265. https://pubmed.ncbi.nlm.nih.gov/22350251/

7. Neznamov GG, Teleshova ES, Gudasheva TA. Potential antidepressant activity of Selank in clinical studies. Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(6):59-62. https://pubmed.ncbi.nlm.nih.gov/23129856/