A synthetic peptide is almost never supplied as a free base. It arrives as a salt, and which salt it is affects both your concentration calculations and, in some assay systems…
Two laboratories can analyse the same peptide and report different purity figures without either being wrong.
Cyclisation is one of the most consequential modifications available to a peptide chemist.
A purity percentage is a summary. The chromatogram it came from carries information the number discards, and reading it is a skill worth having if you buy peptides regularly.
Freeze-drying removes most of the water from a peptide preparation. It does not remove all of it…
"Research grade" is a commercial description, not a defined standard. Knowing what it does not include is more useful than knowing what it does.
"Third-party tested" appears on most peptide supplier sites. It is a meaningful claim only if you know who tested what, and when.
A vial labelled 10 mg does not contain 10 mg of peptide. This is not a supplier shortcut — it follows from how peptides are purified and dried — but it is routinely missed…
Two analytical questions sit behind every research peptide: is this the right molecule, and how much of the vial is that molecule rather than something else?
A Certificate of Analysis (COA) is the document that separates a characterised research compound from an unknown powder. It is also the document most buyers skim without reading.
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SS-31 or Elamipretide? One Compound, Several Naming Conventions5 min readEpitalon or Epithalon? Same Peptide, Two Spellings3 min readResin Choice and Loading in Peptide Synthesis4 min readBinding Assay Formats: What Each One Measures4 min readCompound guides
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