Where Peptide Impurities Come From: Deletion, Truncation, Oxidation and Aggregation
A purity figure says how much of a sample is the target peptide. It says nothing about what the rest is, and the rest has identifiable origins.
How research peptide identity and purity are verified, and how to read the supporting analytical documentation.
A purity figure says how much of a sample is the target peptide. It says nothing about what the rest is, and the rest has identifiable origins.
5 min readA synthetic peptide is almost never supplied as a free base. It arrives as a salt, and which salt it is affects both your concentration calculations and, in some assay systems…
2 min readWeighing a lyophilised peptide accurately is harder than it looks, and the errors are systematic rather than random — they push in one direction and quietly bias every…
2 min readTwo laboratories can analyse the same peptide and report different purity figures without either being wrong.
2 min readA purity percentage is a summary. The chromatogram it came from carries information the number discards, and reading it is a skill worth having if you buy peptides regularly.
2 min readFreeze-drying removes most of the water from a peptide preparation. It does not remove all of it…
2 min read"Research grade" is a commercial description, not a defined standard. Knowing what it does not include is more useful than knowing what it does.
2 min read"Third-party tested" appears on most peptide supplier sites. It is a meaningful claim only if you know who tested what, and when.
5 min readA vial labelled 10 mg does not contain 10 mg of peptide. This is not a supplier shortcut — it follows from how peptides are purified and dried — but it is routinely missed…
3 min readTwo analytical questions sit behind every research peptide: is this the right molecule, and how much of the vial is that molecule rather than something else?
3 min readA Certificate of Analysis (COA) is the document that separates a characterised research compound from an unknown powder. It is also the document most buyers skim without reading.
3 min readThe products offered by ExoLabz are intended solely for research purposes. These products are not for human consumption, are not intended for medical use, and have not been approved by the FDA or Health Canada for any therapeutic or diagnostic purpose. ExoLabz makes no claims regarding the safety, efficacy, or intended use of these products outside of a controlled research environment. By purchasing our products, you agree to use them strictly for scientific research and in compliance with all local laws and regulations.

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