BPC-157 and TB-500 in Canada: Blend or Separate Vials
BPC-157 and TB-500 are sold three ways in Canada: separately, and together in a single vial. The blend is the most searched of the three and the least documented, so here is what is actually in it, and how to work out whether the blend or the separate vials is the better buy for what you are doing.
Two unrelated molecules
They are not variants of each other. BPC-157 is a 15-residue sequence:
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV)
- Molecular mass: 1419.5 g/mol
- CAS registry number: 137525-51-0
TB-500 is shorter, acetylated, and a fragment rather than a whole sequence:
- Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (acetylated LKKTETQ, the thymosin beta-4 17-23 region)
- Molecular mass: 889.0 g/mol
- CAS registry number: 885340-08-9
TB-500 is not thymosin beta-4
This distinction is routinely blurred in listings and it matters when you read the literature. Thymosin beta-4 is a 43-residue protein. TB-500 is a seven-residue acetylated fragment corresponding to the 17-23 region of it. A paper about thymosin beta-4 is not automatically a paper about TB-500, and a certificate for one cannot describe the other — the masses are nowhere near each other.
If a supplier uses the two names interchangeably on the same listing, that is worth a question.
Four prolines, and why the chromatogram matters
BPC-157 contains four proline residues in close succession (positions 3, 4, 5 and 8). Proline-rich sequences are awkward to synthesise cleanly and are a classic source of deletion sequences — chains missing one residue. A deletion product differs from the target by a single proline, 97 daltons, and elutes very close to it on reversed phase.
That is the practical argument for reading the chromatogram rather than the headline figure on this particular compound. A steep gradient can compress a deletion peak under the main one and report a flattering number; a shallower one resolves it and reports a lower figure for identical material. There is a walkthrough in reading an HPLC chromatogram.
Blend or separate vials
A blend puts both compounds in one vial at a fixed ratio. That is convenient and usually cheaper per milligram of total peptide. It also removes a choice: you cannot change the proportion, and you cannot use one without the other.
The analytical consequence is the one people miss. A certificate for a blend should resolve two peaks, because 1419.5 g/mol and 889.0 g/mol are far enough apart to separate cleanly on a competent method. A single peak and a single purity figure on a blend certificate is a question worth asking, not a pass.
Current options are the 10 mg blend, the 20 mg blend, and the separate BPC-157 5 mg, 10 mg, TB-500 5 mg and 10 mg vials. Every one lists its cost per milligram on the page, and the price index puts them side by side so the comparison takes a few seconds rather than a calculator.
What the paperwork covers
Mass confirmation settles identity for each component; RP-HPLC settles uniformity. Neither covers sterility, endotoxin or residual solvents. Certificates for tested lots are on the product page or the certificates page, matched to your vial by cap and crimp colour, and the purity guarantee stands behind them. Everything ships from inside Canada, free and tracked over $200 CAD. The class page is BPC-157 and TB-500 peptides.
All compounds referenced here are supplied by ExoLabz for laboratory research use only. They are not for human or veterinary use, are not authorised by Health Canada as a drug or natural health product, and nothing on this page is guidance on preparation, administration or use.
Weighing the two compounds against each other before you order? Our BPC-157 vs TB-500 comparison lines up identity data, vial sizes and cost per milligram.